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Transcriptome sequencing of Strongyloides ratti

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Strongyloides ratti molecular basis of parasitism

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microRNAs in C. elegans, P. pacificus, and S. ratti: Conserved miRNAs are candidate post-transcriptional regulators of developmental arrest in free-living and parasitic nematodes

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Pristionchus sp. n. 1 VS-2015 Transcriptome or Gene expression

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Strongyloides_ratti_diversity (PRJEB4163 Variations)

Study Overview
Study Name: Strongyloides_ratti_diversity
Submitter: Wellcome Sanger Institute
Project Description: The genome sequences of Strongyloides ratti, S. stercoralis, S. papillosus and S. venezuelensis are providing a clear view of genome diversity within this genus. These species include one human parasite, one parasite of veterinary relevance and two species from rodents, used as laboratory models. We now want to better understand this within-genus diversity, by also looking at the genome diversity with one species, specifically S. ratti. There are different isogenic lines of S. ratti available. (These other lines are recently wild, whereas the S. ratti line sequenced so far has a very long history of laboratory adaptation.) Further, phenotypic data from these lines show that they differ in important infection characteristics. These isofemale lines of S. ratti differ in their fecundity (which, for a parasite is key to transmission potential), particularly in the presence of the host immune response (which, in general suppresses nematode reproduction). These line also differ in the extent to which they reproduce by sexual reproduction outside of the host (compared with the alternative, asexual reproduction). Analogously, this trait (sex vs. no sex) is also affected by the host immune response. Together, this means that these S. ratti lines differ in how they respond to the host immune response, which emphasies that this parasite's interaction with their host is dynamic both on short (i.e. within a worms lifetime) and long (i.e. evolutionary) term time scales. Exploring the genome diversity within this species will therefore begin to illuminate our understanding of these phenotypic differences.
Description provided by ENA

Variants loaded from study PRJEB4163 in the European Variation Archive.
Genetic variation within and among genomes and populations of Strongyloides rati (PRJEB32744 Variations)

Study Overview
Study Name: Genetic variation within and among genomes and populations of Strongyloides rati
Submitter: European Bioinformatics Institute
Project Description: The population genetic structure of parasitic nematode Strongyloides ratti is investigated, and regions of the genome under natural selection are identified with a particular focus on genes implicated in the parasitic lifestyle
Description provided by ENA

Variants loaded from study PRJEB32744 in the European Variation Archive.

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