GET ontology/ancestors/:id

 [
  {
    "definition": "A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase I.",
    "accession": "GO:0000120",
    "name": "RNA polymerase I transcription regulator complex",
    "subsets": [],
    "ontology": "GO",
    "namespace": "cellular_component",
    "synonyms": []
  },
  {
    "synonyms": [],
    "ontology": "GO",
    "namespace": "cellular_component",
    "subsets": [],
    "name": "NuRD complex",
    "accession": "GO:0016581",
    "definition": "An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins."
  },
  {
    "accession": "GO:0017053",
    "definition": "A protein complex that possesses activity that prevents or downregulates transcription.",
    "subsets": [
      "goslim_pir"
    ],
    "name": "transcription repressor complex",
    "ontology": "GO",
    "namespace": "cellular_component",
    "synonyms": [
      "transcription factor inhibitor complex",
      "nuclear transcriptional repressor complex",
      "cytoplasmic transcriptional repressor complex"
    ]
  },
  {
    "accession": "GO:0019185",
    "definition": "A protein complex that recognizes the proximal sequence element of RNA polymerase II and III snRNA promoters.",
    "subsets": [],
    "name": "snRNA-activating protein complex",
    "synonyms": [],
    "namespace": "cellular_component",
    "ontology": "GO"
  },
  {
    "definition": "A heteromeric complex consisting of Cbf1 and basic leucine zipper (bZIP) containing transcriptional activators, Met4 and Met28, that forms over the sequence TCACGTG in the upstream activating sequence (UAS) of genes involved in sulfur amino acid metabolism, resulting in their transcriptional activation.",
    "accession": "GO:0089713",
    "namespace": "cellular_component",
    "ontology": "GO",
    "synonyms": [],
    "name": "Cbf1-Met4-Met28 complex",
    "subsets": []
  },
  {
    "namespace": "cellular_component",
    "ontology": "GO",
    "synonyms": [],
    "subsets": [],
    "name": "RNA polymerase II transcription regulator complex",
    "accession": "GO:0090575",
    "definition": "A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II."
  },
  {
    "accession": "GO:0090576",
    "definition": "A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase III.",
    "namespace": "cellular_component",
    "ontology": "GO",
    "synonyms": [],
    "subsets": [],
    "name": "RNA polymerase III transcription regulator complex"
  },
  {
    "subsets": [],
    "name": "RNA polymerase IV transcription regulator complex",
    "ontology": "GO",
    "namespace": "cellular_component",
    "synonyms": [],
    "accession": "GO:0090577",
    "definition": "A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase IV."
  },
  {
    "definition": "A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase V.",
    "accession": "GO:0090578",
    "namespace": "cellular_component",
    "ontology": "GO",
    "synonyms": [],
    "name": "RNA polymerase V transcription regulator complex",
    "subsets": []
  },
  {
    "namespace": "cellular_component",
    "ontology": "GO",
    "synonyms": [],
    "subsets": [],
    "name": "sigma factor antagonist complex",
    "accession": "GO:1903865",
    "definition": "A protein complex which is capable of sigma factor antagonist activity."
  },
  {
    "accession": "GO:1990198",
    "definition": "A dimeric protein complex containing two ModE subunits. Binds directly to DNA to regulate transcription, and is involved in (positively and negatively) regulating various aspects of molybdenum metabolism.",
    "namespace": "cellular_component",
    "ontology": "GO",
    "synonyms": [
      "ModE dimer"
    ],
    "subsets": [],
    "name": "ModE complex"
  },
  {
    "accession": "GO:1990622",
    "definition": "A heterodimeric protein complex that is composed of CHOP (C/EBP homology protein, GADD153) and ATF3 (activating transcription factor 3) subunits.",
    "synonyms": [
      "CHOP-ATF3 heterodimeric complex",
      "ATF3-CHOP complex",
      "CHOP-ATF3 heterodimer",
      "GADD153-ATF3 complex"
    ],
    "namespace": "cellular_component",
    "ontology": "GO",
    "subsets": [],
    "name": "CHOP-ATF3 complex"
  },
  {
    "definition": "A transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIB contains the TATA-binding protein (TBP) and two Pol III-specific proteins, B'' and BRF.",
    "accession": "GO:0000126",
    "name": "transcription factor TFIIIB complex",
    "subsets": [],
    "ontology": "GO",
    "namespace": "cellular_component",
    "synonyms": []
  },
  {
    "ontology": "GO",
    "namespace": "cellular_component",
    "synonyms": [],
    "subsets": [],
    "name": "transcription factor TFIIIC complex",
    "accession": "GO:0000127",
    "definition": "A heterotrimeric transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIC contains three conserved subunits that associate with the proximal Pol III promoter element, and additional subunits that associate with sequence elements downstream of the promoter and are more diverged among species. It also functions as a boundary element to partition genome content into distinct domains outside Pol III promoter regions."
  },
  {
    "subsets": [
      "goslim_pir"
    ],
    "name": "transcription factor TFIIH core complex",
    "synonyms": [],
    "ontology": "GO",
    "namespace": "cellular_component",
    "accession": "GO:0000439",
    "definition": "The 7 subunit core of TFIIH that is a part of either the general transcription factor holo-TFIIH or the nucleotide-excision repair factor 3 complex. In S. cerevisiae/humans the complex is composed of: Ssl2/XPB, Tfb1/p62, Tfb2/p52, Ssl1/p44, Tfb4/p34, Tfb5/p8 and Rad3/XPD."
  },
  {
    "accession": "GO:0000500",
    "definition": "A complex required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrrn5p, Rrn9p, Rrn10p, histones H3 and H4, and Uaf30p.",
    "subsets": [],
    "name": "RNA polymerase I upstream activating factor complex",
    "synonyms": [],
    "ontology": "GO",
    "namespace": "cellular_component"
  },
  {
    "synonyms": [
      "selectivity factor SL1 complex",
      "TIF-IB"
    ],
    "ontology": "GO",
    "namespace": "cellular_component",
    "subsets": [],
    "name": "RNA polymerase transcription factor SL1 complex",
    "accession": "GO:0005668",
    "definition": "A RNA polymerase I-specific transcription factor complex that contains the TATA-box-binding protein (TBP) and at least three TBP-associated factors including proteins known in mammals as TAFI110, TAFI63 and TAFI48."
  },
  {
    "name": "transcription factor TFIID complex",
    "subsets": [],
    "namespace": "cellular_component",
    "ontology": "GO",
    "synonyms": [],
    "definition": "A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters.",
    "accession": "GO:0005669"
  },
  {
    "synonyms": [],
    "ontology": "GO",
    "namespace": "cellular_component",
    "name": "transcription factor TFIIA complex",
    "subsets": [],
    "definition": "A component of the transcription machinery of RNA Polymerase II. In humans, TFIIA is a heterotrimer composed of an alpha (P35), beta (P19) and gamma subunits (P12).",
    "accession": "GO:0005672"
  },
  {
    "definition": "A transcription factor which in humans consists of a complex of two alpha and two beta chains. Recruits TFIIH to the initiation complex and helps activate both RNA polymerase II and TFIIH.",
    "accession": "GO:0005673",
    "synonyms": [],
    "namespace": "cellular_component",
    "ontology": "GO",
    "name": "transcription factor TFIIE complex",
    "subsets": []
  },
  {
    "synonyms": [],
    "namespace": "cellular_component",
    "ontology": "GO",
    "subsets": [],
    "name": "transcription factor TFIIF complex",
    "accession": "GO:0005674",
    "definition": "A general transcription initiation factor which in humans consists of a heterodimer of an alpha and a beta subunit. Helps recruit RNA polymerase II to the initiation complex and promotes translation elongation."
  },
  {
    "definition": "A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. It is composed of the core TFIIH complex and the TFIIK complex.",
    "accession": "GO:0005675",
    "synonyms": [],
    "namespace": "cellular_component",
    "ontology": "GO",
    "name": "transcription factor TFIIH holo complex",
    "subsets": []
  },
  {
    "ontology": "GO",
    "namespace": "cellular_component",
    "synonyms": [],
    "subsets": [],
    "name": "ecdysone receptor holocomplex",
    "accession": "GO:0008230",
    "definition": "A heterodimeric complex containing the products of the insect genes Ecdysone receptor (EcR) and ultraspiracle (usp). Binding of ecdysone promotes association between the two subunits, and the receptor complex then initiates molting and metamorphosis by binding DNA and regulating the transcription of target genes."
  },
  {
    "synonyms": [],
    "namespace": "cellular_component",
    "ontology": "GO",
    "name": "core-binding factor complex",
    "subsets": [],
    "definition": "A heterodimeric transcription factor complex that contains an alpha subunit (Runx1, Runx2 or Runx3 in human) that binds DNA and a non-DNA-binding beta subunit (CBFbeta), and binds to a consensus sequence 5'-YGYGGTY-3' found in several enhancers and promoters; the beta subunit enhances the DNA binding of the alpha subunit.",
    "accession": "GO:0016513"
  },
  {
    "definition": "A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; functions as both an activator and a repressor, depending on its interacting cofactors. Typically trimeric consisting of NFYA, NFYB and NFYC subunits. In Saccharomyces, it activates the transcription of genes in response to growth in a nonfermentable carbon source and consists of four known subunits: HAP2, HAP3, HAP4 and HAP5.",
    "accession": "GO:0016602",
    "name": "CCAAT-binding factor complex",
    "subsets": [],
    "synonyms": [
      "nuclear transcription factor Y complex",
      "NF-Y transcription factor complex",
      "CBF complex"
    ],
    "namespace": "cellular_component",
    "ontology": "GO"
  },
  {
    "subsets": [],
    "name": "insulin control element activator complex",
    "synonyms": [],
    "namespace": "cellular_component",
    "ontology": "GO",
    "accession": "GO:0030232",
    "definition": "Transcription factor complex that binds to the insulin control element (ICE), a DNA sequence element found within the 5'-flanking region of the insulin gene, and activates ICE-mediated transcription."
  },
  {
    "synonyms": [],
    "ontology": "GO",
    "namespace": "cellular_component",
    "name": "MBF transcription complex",
    "subsets": [],
    "definition": "A protein complex that binds to the Mlu1 cell cycle box (MCB) promoter element, consensus sequence ACGCGN, and is involved in regulation of transcription during the G1/S transition of the cell cycle. In Saccharomyces, the complex contains a heterodimer of the DNA binding protein Mbp1p and the activator Swi6p, and is associated with additional proteins known as Nrm1p, Msa1p, and Msa2p; in Schizosaccharomyces the complex contains Res1p, Res2p, and Cdc10p.",
    "accession": "GO:0030907"
  },
  {
    "accession": "GO:0032444",
    "definition": "A transcriptionally active complex that binds to an activin response element (ARE) in the promoter of target genes, and is composed of two SMAD2 proteins, one SMAD4 protein and a Forkhead activin signal transducer (FAST) transcription factor.",
    "ontology": "GO",
    "namespace": "cellular_component",
    "synonyms": [],
    "subsets": [],
    "name": "activin responsive factor complex"
  },
  {
    "name": "transcription factor TFTC complex",
    "subsets": [],
    "synonyms": [],
    "namespace": "cellular_component",
    "ontology": "GO",
    "definition": "A protein complex that does not contain either a TATA-binding protein (TBP) or a TBP-like factor, but is composed of several TAFIIs and other proteins, including a histone acetyltransferase. This complex is able to nucleate transcription initiation by RNA polymerase II, can mediate transcriptional activation, and has histone acetyltransferase activity.",
    "accession": "GO:0033276"
  },
  {
    "accession": "GO:0033309",
    "definition": "A protein complex that binds to the Swi4/6 cell cycle box (SCB) promoter element, consensus sequence CRCGAAA, and activates transcription during the G1/S transition of the cell cycle. In Saccharomyces, the complex contains a heterodimer of the DNA binding protein Swi4p and the activator Swi6p, and is associated with additional proteins known as Whi5p and Msa1p.",
    "namespace": "cellular_component",
    "ontology": "GO",
    "synonyms": [
      "SBF complex"
    ],
    "subsets": [],
    "name": "SBF transcription complex"
  },
  {
    "ontology": "GO",
    "namespace": "cellular_component",
    "synonyms": [],
    "name": "SMN-Gemin2 complex",
    "subsets": [],
    "definition": "A protein complex that contains the survival motor neuron (SMN) protein and Gemin2; may form the stable core of the larger SMN complex.",
    "accession": "GO:0034718"
  },
  {
    "definition": "A protein complex that contains TFIIIC, topoisomerase 1, and Sub1/PC4. Characterized in human, the complex is involved in regulating transcription from RNA polymerase III (Pol III) promoters. Topoisomerase 1 and Sub1 enhance the accuracy of transcription termination, and promote reinitiation by Pol III.",
    "accession": "GO:0034740",
    "synonyms": [],
    "ontology": "GO",
    "namespace": "cellular_component",
    "name": "TFIIIC-TOP1-SUB1 complex",
    "subsets": []
  },
  {
    "accession": "GO:0035189",
    "definition": "A multiprotein complex containing a heterodimeric E2F transcription factor and a Retinoblastoma (Rb) family member. This complex is capable of repressing transcription of E2F-regulated genes in order to regulate cell cycle progression.",
    "subsets": [],
    "name": "Rb-E2F complex",
    "synonyms": [],
    "namespace": "cellular_component",
    "ontology": "GO"
  },
  {
    "name": "transcription factor AP-1 complex",
    "subsets": [],
    "synonyms": [
      "transcription factor AP1 complex",
      "AP-1 complex",
      "AP1 complex",
      "Activating protein 1 complex"
    ],
    "namespace": "cellular_component",
    "ontology": "GO",
    "definition": "A heterodimeric transcription factor complex composed of proteins from the c-Fos, c-Jun, activating transcription factor (ATF) or JDP families. The subunits contain a basic leucine zipper (bZIP) domain that is essential for dimerization and DNA binding. Jun-Fos heterodimers bind preferentially to a heptamer consensus sequence (TPA responsive element (TRE)), whereas Jun-ATF dimers bind the cyclic AMP responsive element (CRE) to regulate transcription of target genes.",
    "accession": "GO:0035976"
  },
  {
    "accession": "GO:0036411",
    "definition": "A trimeric protein complex containing a H-NS homodimer and a Cnu monomer. In bacteria, this complex negatively regulates transcription of a range of genes.",
    "synonyms": [],
    "namespace": "cellular_component",
    "ontology": "GO",
    "subsets": [],
    "name": "H-NS-Cnu complex"
  },
  {
    "name": "CHOP-C/EBP complex",
    "subsets": [],
    "ontology": "GO",
    "namespace": "cellular_component",
    "synonyms": [
      "CHOP-C/EBP heterodimer",
      "CHOP-C/EBP dimer",
      "GADD153-C/EBP complex",
      "GADD153-C/EBP-alpha complex"
    ],
    "definition": "A heterodimeric protein complex that is composed of the transcription factor CHOP (GADD153) and a member of the C/EBP family of transcription factors.",
    "accession": "GO:0036488"
  },
  {
    "accession": "GO:0062071",
    "definition": "A transcription factor complex composed of a homeodomain protein and the M-specific peptide Mi that acts at the regulatory region of genes required for the activation of meiosis.",
    "synonyms": [],
    "ontology": "GO",
    "namespace": "cellular_component",
    "subsets": [],
    "name": "Pi Mi complex"
  },
  {
    "accession": "GO:0070264",
    "definition": "A transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIE contains a specific subset of ribosomal proteins.",
    "subsets": [],
    "name": "transcription factor TFIIIE complex",
    "synonyms": [],
    "ontology": "GO",
    "namespace": "cellular_component"
  },
  {
    "accession": "GO:0070514",
    "definition": "A transcription factor complex that contains the serum response factor (SRF) and the basic helix-loop-helix proteins myogenin and E12, and is involved in activating transcription of muscle-specific genes.",
    "ontology": "GO",
    "namespace": "cellular_component",
    "synonyms": [],
    "subsets": [],
    "name": "SRF-myogenin-E12 complex"
  },
  {
    "accession": "GO:0070721",
    "definition": "A transcription factor complex that consists of a Stat1-Stat2 heterodimer and the IRF9 protein.",
    "subsets": [],
    "name": "ISGF3 complex",
    "synonyms": [
      "interferon-stimulated gene factor 3 transcription complex"
    ],
    "ontology": "GO",
    "namespace": "cellular_component"
  },
  {
    "ontology": "GO",
    "namespace": "cellular_component",
    "synonyms": [
      "Snf2/Hdac repressive complex",
      "Snf2/HDAC containing repressor complex"
    ],
    "subsets": [],
    "name": "SHREC complex",
    "accession": "GO:0070824",
    "definition": "A histone deacetylase complex that contains a core of four proteins -- Clr1, Clr2, Clr3, and Mit1 in fission yeast -- and localizes to all heterochromatic regions in the genome as well as some euchromatic sites. The complex is involved in regulating nucleosome positioning to assemble higher-order chromatin structures."
  },
  {
    "definition": "A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.",
    "accession": "GO:0070847",
    "ontology": "GO",
    "namespace": "cellular_component",
    "synonyms": [
      "C mediator complex",
      "S mediator complex"
    ],
    "name": "core mediator complex",
    "subsets": []
  },
  {
    "accession": "GO:0070860",
    "definition": "A RNA polymerase I-specific transcription factor complex that is required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrn6p, Rrn7p, and Rrn11p.",
    "ontology": "GO",
    "namespace": "cellular_component",
    "synonyms": [],
    "subsets": [],
    "name": "RNA polymerase I core factor complex"
  },
  {
    "name": "heteromeric SMAD protein complex",
    "subsets": [],
    "synonyms": [
      "SMAD2-SMAD4 protein complex"
    ],
    "namespace": "cellular_component",
    "ontology": "GO",
    "definition": "A protein complex composed of SMAD family proteins, a transcription factor complex which binds to the promoters of target genes and recruits co-activators and histone acetyltransferases, facilitating transcription. Phosphorylation of the non-SMAD4 subunit(s) enables binding of SMAD4 to form heteromeric complexes that enter the nucleus to initiate gene transcription. DNA-binding specificity is conferred by other transcription factors binding to SMAD complexes. Interactions with coactivators or corepressors modulate their transcriptional activity. Can be heterotrimeric or heterodimeric.",
    "accession": "GO:0071144"
  },
  {
    "accession": "GO:0071943",
    "definition": "A transcription factor complex that consists of a heterodimer of the bHLH-ZIP proteins Myc and Max.",
    "subsets": [],
    "name": "Myc-Max complex",
    "ontology": "GO",
    "namespace": "cellular_component",
    "synonyms": []
  },
  {
    "definition": "A heterodimeric complex consisting of Zn(2)Cys(6) containing transcription factors Pip2 and Oaf1. It binds to the oleate response element (ORE), found in the promoters of fatty acid-inducible genes in Saccharomyces where, in the presence of oleate this bound complex activates the transcription of genes encoding peroxisomal proteins.",
    "accession": "GO:0089716",
    "name": "Pip2-Oaf1 complex",
    "subsets": [],
    "synonyms": [],
    "ontology": "GO",
    "namespace": "cellular_component"
  },
  {
    "subsets": [],
    "name": "RNA polymerase I transcription repressor complex",
    "namespace": "cellular_component",
    "ontology": "GO",
    "synonyms": [],
    "accession": "GO:0090570",
    "definition": "A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase I promoter."
  },
  {
    "accession": "GO:0090571",
    "definition": "A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase II promoter.",
    "ontology": "GO",
    "namespace": "cellular_component",
    "synonyms": [],
    "subsets": [],
    "name": "RNA polymerase II transcription repressor complex"
  },
  {
    "subsets": [],
    "name": "RNA polymerase III transcription repressor complex",
    "namespace": "cellular_component",
    "ontology": "GO",
    "synonyms": [],
    "accession": "GO:0090572",
    "definition": "A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase III promoter."
  },
  {
    "ontology": "GO",
    "namespace": "cellular_component",
    "synonyms": [],
    "name": "RNA polymerase IV transcription repressor complex",
    "subsets": [],
    "definition": "A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase IV promoter.",
    "accession": "GO:0090573"
  },
  {
    "synonyms": [],
    "ontology": "GO",
    "namespace": "cellular_component",
    "name": "RNA polymerase V transcription repressor complex",
    "subsets": [],
    "definition": "A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase V promoter.",
    "accession": "GO:0090574"
  },
  {
    "definition": "A protein complex that contains a MADS-box protein and two forkhead domain proteins, and binds to and regulates transcription from promoters of genes transcribed during the M/G1 transition of the cell cycle. In Schizosaccharomyces pombe, the complex contains the MADS-box protein Mbx1 and two forkhead proteins, Sep1 and Fkh2.",
    "accession": "GO:0097221",
    "ontology": "GO",
    "namespace": "cellular_component",
    "synonyms": [
      "PBF transcription complex"
    ],
    "name": "M/G1 phase-specific MADS box-forkhead transcription factor complex",
    "subsets": []
  },
  {
    "accession": "GO:0099053",
    "definition": "A protein complex that contains TRIP4 (ASC1) and acts a transcriptional coactivator by interacting with transcription factors such as NF-kappa B. In humans this complex has 4 subunits: TRIP4 + ASCC1-3.",
    "namespace": "cellular_component",
    "ontology": "GO",
    "synonyms": [
      "ASC-1 complex"
    ],
    "subsets": [],
    "name": "activating signal cointegrator 1 complex"
  },
  {
    "namespace": "cellular_component",
    "ontology": "GO",
    "synonyms": [],
    "subsets": [],
    "name": "toxin-antitoxin complex",
    "accession": "GO:0110001",
    "definition": "A bacterial protein complex that neutralises its own toxin by complexing the toxin with the antitoxin. The antitoxin can be either a protein or an RNA. The neutralising toxin-antitoxin complex also acts as a transcriptional repressor of the toxin-antitoxin operon."
  },
  {
    "synonyms": [],
    "ontology": "GO",
    "namespace": "cellular_component",
    "subsets": [],
    "name": "SHREC2 complex",
    "accession": "GO:0110129",
    "definition": "A histone deacetylase complex formed by the association of an HP1 protein with a SHREC complex. The SHREC2 complex is required for deacetylation of H3K14, and mediates transcriptional gene silencing by limiting RNA polymerase II access to heterochromatin. In fission yeast, the complex contains the SHREC subunits Clr1, Clr2, Clr3, and Mit1, and the HP1 protein Chp2."
  },
  {
    "namespace": "cellular_component",
    "ontology": "GO",
    "synonyms": [],
    "subsets": [],
    "name": "TEAD-YAP complex",
    "accession": "GO:0140552",
    "definition": "A transcription factor complex that is composed of the one DNA binding protein of the TEAD family and the transcriptional coactivator YAP."
  },
  {
    "subsets": [],
    "name": "upstream stimulatory factor complex",
    "ontology": "GO",
    "namespace": "cellular_component",
    "synonyms": [],
    "accession": "GO:1990378",
    "definition": "A protein complex capable of sequence-specific DNA binding RNA polymerase II transcription factor activity through binding to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3'). Found in a variety of viral and cellular promoters."
  },
  {
    "definition": "A DNA-binding transcription factor complex consisting of CSL and mastermind proteins in complex with the cleaved, intracellular domain of Notch. It is required for both repression and activation of Notch target genes.",
    "accession": "GO:1990433",
    "synonyms": [],
    "namespace": "cellular_component",
    "ontology": "GO",
    "name": "CSL-Notch-Mastermind transcription factor complex",
    "subsets": []
  },
  {
    "synonyms": [],
    "namespace": "cellular_component",
    "ontology": "GO",
    "name": "Cry-Per complex",
    "subsets": [],
    "definition": "Nuclear transcriptional repressor complex that is capable of negatively regulating CLOCK-BMAL-dependent transactivation of genes in a delayed negative feedback manner which generates circadian rhythms.",
    "accession": "GO:1990512"
  },
  {
    "namespace": "cellular_component",
    "ontology": "GO",
    "synonyms": [],
    "name": "CLOCK-BMAL transcription complex",
    "subsets": [],
    "definition": "Transcription factor complex which interacts with E-box regulatory elements in target genes, including Period (Per1, Per2, Per3) and Cryptochrome (Cry1, Cry2), to activate their transcription during the daytime. The CRY-PER complexes inhibit CLOCK-BMAL1-driven transcription in a negative feedback loop to generate circadian rhythms.",
    "accession": "GO:1990513"
  },
  {
    "accession": "GO:1990589",
    "definition": "Transcription factor complex consisting of ATF4 and CREB1 subunits that is capable of binding to cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') as part of the positive regulation of transcription. Regulatory targets include the GRP78 (HSPA5) promoter in humans, whose activation by this complex is part of the ER stress response pathway.",
    "synonyms": [],
    "namespace": "cellular_component",
    "ontology": "GO",
    "subsets": [],
    "name": "ATF4-CREB1 transcription factor complex"
  },
  {
    "namespace": "cellular_component",
    "ontology": "GO",
    "synonyms": [],
    "name": "ATF1-ATF4 transcription factor complex",
    "subsets": [],
    "definition": "Transcription factor complex consisting of ATF1 and ATF4 subunits that is capable of binding to cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') of the GRP78 (HSPA5) promoter. Involved in the ER stress response pathway.",
    "accession": "GO:1990590"
  },
  {
    "ontology": "GO",
    "namespace": "cellular_component",
    "synonyms": [
      "CHOP-ATF4 heterodimer",
      "CHOP-CREB-2 complex",
      "GADD153-ATF4 complex",
      "ATF4-CHOP heterodimer",
      "CHOP/ATF4 complex"
    ],
    "name": "CHOP-ATF4 complex",
    "subsets": [],
    "definition": "A heterodimeric transcription factor complex that is composed of CHOP (C/EBP homology protein, GADD153) and ATF4 (activating transcription factor 4, also known as cAMP response element binding protein-2/CREB-2) subunits.",
    "accession": "GO:1990617"
  },
  {
    "synonyms": [],
    "namespace": "cellular_component",
    "ontology": "GO",
    "subsets": [],
    "name": "C/EBP complex",
    "accession": "GO:1990647",
    "definition": "A dimeric, sequence specific DNA-binding transcription factor complex regulating the expression of genes involved in immune and inflammatory responses. Exists at least as alpha and beta homodimeric forms. Binds to regulatory regions of several acute-phase and cytokines genes and probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Transcription factor activity is inhibited by binding of CHOP forming heterodimers with alternative transcription factor activities."
  },
  {
    "definition": "A transcription factor complex formed by two or more subunits of Nkx-2.5. Nkx-2.5 is an evolutionary conserved transcription factor important for the specification and differentiation of cardiomyocytes during heart development. It is also required for spleen development. It binds DNA either as a monomer, or a homodimer, or a heterodimer complex to activate or inhibit expression of genes.",
    "accession": "GO:1990664",
    "name": "Nkx-2.5 complex",
    "subsets": [],
    "namespace": "cellular_component",
    "ontology": "GO",
    "synonyms": [
      "NKX.2-5 homodimer complex",
      "NKX2E homodimer complex",
      "NKX2.5 complex"
    ]
  },
  {
    "definition": "A protein complex that contains beta-catenin and a member of the T-cell factor (TCF)/lymphoid enhancer binding factor (LEF) family of transcription factors.",
    "accession": "GO:1990907",
    "ontology": "GO",
    "namespace": "cellular_component",
    "synonyms": [
      "beta-catenin/LEF complex",
      "beta-catenin/T-cell factor complex",
      "beta-catenin/lymphoid enhancer binding factor complex"
    ],
    "name": "beta-catenin-TCF complex",
    "subsets": []
  },
  {
    "ontology": "GO",
    "namespace": "cellular_component",
    "synonyms": [],
    "subsets": [],
    "name": "core TFIIH complex portion of holo TFIIH complex",
    "accession": "GO:0000438",
    "definition": "The core TFIIH complex when it is part of the general transcription factor TFIIH."
  },
  {
    "subsets": [],
    "name": "core TFIIH complex portion of NEF3 complex",
    "ontology": "GO",
    "namespace": "cellular_component",
    "synonyms": [],
    "accession": "GO:0000440",
    "definition": "The core TFIIH complex when it is part of the nucleotide-excision repair factor 3 (NEF3)."
  },
  {
    "accession": "GO:0008231",
    "definition": "A protein complex consisting of a heterodimer of Ecdysone receptor (EcR) and ultraspiracle (usp) plus an associated corepressor such as SMRTER, which represses transcription of target genes.",
    "synonyms": [
      "repressor ecdysone receptor holocomplex"
    ],
    "ontology": "GO",
    "namespace": "cellular_component",
    "subsets": [],
    "name": "repressor ecdysone receptor complex"
  },
  {
    "name": "activator ecdysone receptor complex",
    "subsets": [],
    "synonyms": [
      "activator ecdysone receptor holocomplex"
    ],
    "ontology": "GO",
    "namespace": "cellular_component",
    "definition": "A protein complex consisting of a heterodimer of Ecdysone receptor (EcR) and ultraspiracle (usp) bound to the ligand ecdysone, which activates transcription of target genes.",
    "accession": "GO:0008232"
  },
  {
    "definition": "A heterodimeric protein complex that can stably associate with TATA-binding protein on promoters, thereby preventing the assembly of transcription factors TFIIA and TFIIB and leading to repression of RNA polymerase II transcription. The two subunits, NC2alpha (Drap1) and NC2beta (Dr1), dimerize through histone fold domains of the H2A/H2B type present in the amino termini.",
    "accession": "GO:0017054",
    "name": "negative cofactor 2 complex",
    "subsets": [],
    "synonyms": [],
    "namespace": "cellular_component",
    "ontology": "GO"
  },
  {
    "namespace": "cellular_component",
    "ontology": "GO",
    "synonyms": [],
    "subsets": [],
    "name": "transcription factor TFIIIB-alpha complex",
    "accession": "GO:0034732",
    "definition": "A transcription factor TFIIIB-beta complex that contains the TATA-binding protein (TBP), B'' and a specialized homolog of the conserved subunit BRF referred to as BRFU or TFIIIB50, which found in human but not conserved in yeast; the complex is involved in the regulation of transcription from type 3 (upstream) RNA polymerase III promoters."
  },
  {
    "synonyms": [],
    "ontology": "GO",
    "namespace": "cellular_component",
    "subsets": [],
    "name": "transcription factor TFIIIB-beta complex",
    "accession": "GO:0034733",
    "definition": "A transcription factor TFIIIB-beta complex that contains the TATA-binding protein (TBP), B'' and BRF, and is involved in the regulation of transcription from type 2 RNA polymerase III promoters."
  },
  {
    "namespace": "cellular_component",
    "ontology": "GO",
    "synonyms": [],
    "subsets": [],
    "name": "transcription factor TFIIIC1 complex",
    "accession": "GO:0034734",
    "definition": "A transcription factor complex that forms part of the TFIIIC complex, observed in human. The complex is poorly characterized, but contains the 250-kDa form of HsBdp1, and is thought to include nuclear factor 1 (NF1). It stimulates binding by human TFIIIC2 and is required for transcription activity."
  },
  {
    "accession": "GO:0034735",
    "definition": "A transcription factor complex that forms part of the TFIIIC complex, observed in human; composed of five subunits (GTF3C1/hTFIIIC220/TFIIICalpha, GTF3C2/hTFIIIC110/TFIIICbeta, GTF3C3/hTFIIIC102/TFIIICgamma, GTF3C4/hTFIIIC90/TFIIICdelta and GTF3C5/hTFIIIC63/TFIIICepsilon in human) that together recognize the type 2 RNA polymerase III promoter.",
    "subsets": [],
    "name": "transcription factor TFIIIC2 complex",
    "namespace": "cellular_component",
    "ontology": "GO",
    "synonyms": []
  },
  {
    "accession": "GO:0070176",
    "definition": "A transcriptional repressor complex that contains the lin-9, lin-35, lin-37, lin-52, lin-53, lin-5is involved in 4-, dpl-1 and efl-1 proteins, and is involved in cell fate specification.",
    "synonyms": [
      "DP/Rb/MuvB"
    ],
    "ontology": "GO",
    "namespace": "cellular_component",
    "subsets": [],
    "name": "DRM complex"
  },
  {
    "subsets": [],
    "name": "beta-catenin-TCF7L2 complex",
    "namespace": "cellular_component",
    "ontology": "GO",
    "synonyms": [
      "beta-catenin-TCF4 complex"
    ],
    "accession": "GO:0070369",
    "definition": "A protein complex that contains beta-catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription."
  },
  {
    "subsets": [],
    "name": "Mad-Max-mSin3A complex",
    "ontology": "GO",
    "namespace": "cellular_component",
    "synonyms": [],
    "accession": "GO:0070439",
    "definition": "A transcriptional repressor complex that contains a heterodimer of the bHLH-ZIP proteins Mad and Max, plus mSin3A, a homolog of the yeast Sin3p."
  },
  {
    "ontology": "GO",
    "namespace": "cellular_component",
    "synonyms": [],
    "subsets": [],
    "name": "Mad-Max-mSin3B complex",
    "accession": "GO:0070440",
    "definition": "A transcriptional repressor complex that contains a heterodimer of the bHLH-ZIP proteins Mad and Max, plus mSin3B, a homolog of the yeast Sin3p."
  },
  {
    "accession": "GO:0070443",
    "definition": "A transcriptional repressor complex that consists of a heterodimer of the bHLH-ZIP proteins Mad and Max.",
    "subsets": [],
    "name": "Mad-Max complex",
    "namespace": "cellular_component",
    "ontology": "GO",
    "synonyms": []
  },
  {
    "synonyms": [
      "TFIID complex, B-cell specific"
    ],
    "ontology": "GO",
    "namespace": "cellular_component",
    "subsets": [],
    "name": "TAF4B-containing transcription factor TFIID complex",
    "accession": "GO:0070556",
    "definition": "A transcription factor TFIID complex that contains the TBP-associated factor TAF4B (also known as TAFII105 in human), a cell-type-specific variant of TAF4."
  },
  {
    "definition": "A transcriptional repressor complex that consists of a heterodimer of the proteins Tle3 (also known as Grg3b) and Aes (Grg5), which are homologs of the Drosophila groucho gene product.",
    "accession": "GO:0070722",
    "ontology": "GO",
    "namespace": "cellular_component",
    "synonyms": [
      "Grg3b-Grg5 complex"
    ],
    "name": "Tle3-Aes complex",
    "subsets": []
  },
  {
    "definition": "A transcription factor complex that forms part of the holo TFIIH complex. In Saccharomyces/human, TFIIK contains Ccl1p/Cyclin H, Tfb3p/MAT1 and Kin28p/CDK7.",
    "accession": "GO:0070985",
    "synonyms": [
      "Mcs6/Mcs2/Pmh1 complex",
      "cyclin H-CDK7 complex"
    ],
    "namespace": "cellular_component",
    "ontology": "GO",
    "name": "transcription factor TFIIK complex",
    "subsets": []
  },
  {
    "synonyms": [],
    "ontology": "GO",
    "namespace": "cellular_component",
    "name": "Cyc8(Ssn6)-Tup1 general repressor complex",
    "subsets": [],
    "definition": "A corepressor complex containing the WD-repeat protein Tup1p (S. cerevisiae) and Tup11/Tup12 (fission yeast) and the TPR repeat protein Cyc8p (S. cerevisiae) ssn6 (fission yeast) that is recruited to target genes by DNA-bound repressor proteins preferentially at regions where histones are deacetylated by the Clr6 class I HDAC, and recruits the SWI/SNF and SAGA complexes to promoters.",
    "accession": "GO:0160051"
  },
  {
    "synonyms": [],
    "namespace": "cellular_component",
    "ontology": "GO",
    "name": "atf1-pcr1 complex",
    "subsets": [],
    "definition": "A heterodimeric transcription factor complex composed of the bZIP proteins atf1 and pcr1. The heterodimer binds m26 sites (homologous to CRE).",
    "accession": "GO:1990243"
  },
  {
    "namespace": "cellular_component",
    "ontology": "GO",
    "synonyms": [],
    "name": "beta-catenin-ICAT complex",
    "subsets": [],
    "definition": "Transcription factor complex that inhibits binding of Tcf to beta-catenin while preserving interaction of catenin with cadherin thus inhibiting transcription mediated by beta-catenin-Tcf complex.",
    "accession": "GO:1990711"
  }
]