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Brugia malayi

BioProject PRJNA10729 | Data Source WormBase | Taxonomy ID 6279

About Brugia malayi

The nematode Brugia malayi is a gonochoristic (male-female) filarial parasite, of medical interest because it infects mosquito vectors (Aedes, Anopheles and Culex) and humans, and is phylogenetically representative of other infectious nematodes. Infection of humans by B. malayi causes filariasis, also known as elephantiasis. B. malayi is readily infective in laboratory animals.

Genome assembly: Bmal-4.0

The B.malayi genome was first sequenced at the former TIGR institute and described by Ghedin et al (2007). In 2012 a new genome sequencing, assembly and curation project was conducted on the FR3 strain as a cooperative effort between WormBase and the University of Pittsburgh. An improvement of this assembly by including PacBio and optical mapping data was conducted in 2016, allowing the scaffolding of chromosomes as well as better representation of repetitive regions. This sequenced FR3 strain is available at the Filiarisis Research Reagent Center.
A publication covering the new assembly is in progress, and the consortium reserves itself the right of first publication.

Gene annotation

The gene structures are actively curated by WormBase.

What can I find? Protein-coding and non-coding genes, splice variants, cDNA and protein sequences, non-coding RNAs.

Comparative genomics

What can I find? Orthologues, paralogues, and gene trees across multiple species.

More information and statistics

Key Publications

  • Ghedin E, Wang S, Spiro D, Caler E, Zhao Q, Crabtree J, Allen JE, Delcher AL, Guiliano DB, Miranda-Saavedra D, Angiuoli SV, Creasy T, Amedeo P, Haas B, El-Sayed NM, Wortman JR, Feldblyum T, Tallon L, Schatz M, Shumway M, Koo H, Salzberg SL, Schobel S, Pertea M, Pop M, White O, Barton GJ, Carlow CK, Crawford MJ, Daub J, Dimmic MW, Estes CF, Foster JM, Ganatra M, Gregory WF, Johnson NM, Jin J, Komuniecki R, Korf I, Kumar S, Laney S, Li BW, Li W, Lindblom TH, Lustigman S, Ma D, Maina CV, Martin DM, McCarter JP, McReynolds L, Mitreva M, Nutman TB, Parkinson J, Peregrín-Alvarez JM, Poole C, Ren Q, Saunders L, Sluder AE, Smith K, Stanke M, Unnasch TR, Ware J, Wei AD, Weil G, Williams DJ, Zhang Y, Williams SA, Fraser-Liggett C, Slatko B, Blaxter ML, Scott AL. Draft genome of the filarial nematode parasite Brugia malayi. Science, 2007;317(5845):1756-1760

Statistics

AssemblyBmal-4.0, Dec 2015
StrainFR3
Database VersionWBPS8
Genome Size88,235,797
Data SourceWormBase
Annotation VersionWS254

Gene counts

Coding genes11,021
Non coding genes455
Small non coding genes455
Pseudogenes306
Gene transcripts14,798

Assembly Statistics

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This widget has been derived from the assembly-stats code developed by the Lepbase project at the University of Edinburgh

About this species