Brugia pahangi
BioProject PRJEB497 | Data Source Wellcome Sanger Institute | Taxonomy ID 6280
About Brugia pahangi
Brugia pahangi is a filarial parasite that is transmitted to domestic cats and dogs in South East Asia when infected mosquitoes take a blood meal. It is used as a model for filarial infections because it is relatively easy to maintain the laboratory. It is closely related to the human parasite Brugia malayi and studies suggest that it may be zoonotic, developing to maturity in humans. \n
\n*Announcement:* The Devaney group have small numbers of adult B. pahangi and larger numbers of Mf available to others for research purposes. If this would be useful, please contact eileen.devaney@glasgow.ac.uk with approximate numbers, life stage required and whether fresh or frozen material is suitable. The B. pahangi life cycle is funded by a grant from the Wellcome Trust (208390/Z/17/Z).
Genome Assembly & Annotation
Assembly
The draft genome assembly was produced by the Parasite Genomic group at the Wellcome Trust Sanger Institute, in collaboration with Eileen Devaney (University of Glasgow) as part of the 50 Helminth Genomes project. The assembly uses Illumina paired-end sequencing followed by an in-house genome assembly pipeline comprising various steps, including contig assembly, scaffolding, gap-filling and error-correction.
Annotation
The gene predictions were made by the Parasite Genomics group at the Wellcome Trust Sanger Institute and WormBase, as part of the 50 Helminth Genomes project. An in-house pipeline was developed that used MAKER to generate high-quality annotations by integrating evidence from multiple sources: ab initio gene predictions from AUGUSTUS, GeneMark-ES, and SNAP; projected annotation from C. elegans (using GenBlastG) and the taxonomically nearest reference helminth genome (using RATT); and ESTs, mRNAs and proteins from related organisms aligned to the genome using BLAST, with refinement of alignments using Exonerate.
Downloads
Tools
Key Publications
- International Helminth Genomes Consortium. Comparative genomics of the major parasitic worms. Nat Genet, 2019;51(1):163-174
Assembly Statistics
| Assembly | B_pahangi_Glasgow_0011_upd, GCA_900618355.1 |
| Strain | Scotland/Glasgow |
| Database Version | WBPS19 |
| Genome Size | 90,545,113 |
| Data Source | Wellcome Sanger Institute |
| Annotation Version | 2014-06-50HGPpatch |
Gene counts
| Coding genes | 14,674 |
| Gene transcripts | 14,674 |
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