WormBase ParaSite HomeVersion: WBPS17 (WS282)

Necator americanus

BioProject PRJNA72135 | Data Source McDonnell Genome Institute | Taxonomy ID 51031

About Necator americanus

The nematode Necator americanus, or human hookworm, lives in the intestines and is particularly harmful to children, causing chronic anemia, stunting growth and impairing intellectual development. N. americanus is the most prevalent species of human parasite and therefore important from a public health standpoint.

Genome Assembly & Annotation

Assembly

The N. americanus genome was sequenced by the Mitreva laboratory at the Genome Institute of Washington University, as described by Tang et al (2014).

Annotation

The gene predictions for this assembly were drastically updated in WBPS17 by Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, as described by Logan et al (2020). Gene models were generated using the MAKER pipeline. Publicly available RNASeq data, protein sequences of related species from SwissProt UniRef100 and WormBase ParaSite, previously generated models by Tang et. al. and ab initio gene predictions were provided to MAKER and BRAKER as further evidence. Final gene models were created using GeneMark and Augustus within BRAKER.

Key Publications

  • Tang YT, Gao X, Rosa BA, Abubucker S, Hallsworth-Pepin K, Martin J, Tyagi R, Heizer E, Zhang X, Bhonagiri-Palsikar V, Minx P, Warren WC, Wang Q, Zhan B, Hotez PJ, Sternberg PW, Dougall A, Gaze ST, Mulvenna J, Sotillo J, Ranganathan S, Rabelo EM, Wilson RW, Felgner PL, Bethony J, Hawdon JM, Gasser RB, Loukas A, Mitreva M. Genome of the human hookworm Necator americanus. Nat Genet, 2014;46(3):261-269
  • Logan J, Pearson MS, Manda SS, Choi YJ, Field M, Eichenberger RM, Mulvenna J, Nagaraj SH, Fujiwara RT, Gazzinelli-Guimaraes P, Bueno L, Mati V, Bethony JM, Mitreva M, Sotillo J, Loukas A. Comprehensive analysis of the secreted proteome of adult Necator americanus hookworms. PLoS Negl Trop Dis, 2020;14(5):e0008237

Assembly Statistics

AssemblyN__americanus_v1, GCF_000507365.1
StrainN. amaericanus Hunan isolate
Database VersionWBPS17
Genome Size244,075,060
Data SourceMcDonnell Genome Institute
Annotation Version2021-11-WormBase

Gene counts

Coding genes15,728
Gene transcripts15,728

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