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Nippostrongylus brasiliensis

BioProject PRJEB511 | Data Source Wellcome Sanger Institute | Taxonomy ID 27835

About Nippostrongylus brasiliensis

The nematode Nippostrongylus brasiliensis, rat hookworm, is a gastrointestinal parasite of rats. It is one of the most widely studied helminth models: it is relatively easy to maintain in the lab and is a close relative of human hookworms.

Genome Assembly & Annotation


The draft genome assembly was produced by the Parasite Genomic group at the Wellcome Trust Sanger Institute, in collaboration with Rick Maizels (Edinburgh University) as part of the 50 Helminth Genomes project. The assembly uses Illumina paired-end sequencing followed by an in-house genome assembly pipeline comprising various steps, including contig assembly, scaffolding, gap-filling and error-correction.


The gene predictions were made by the Parasite Genomics group at the Wellcome Trust Sanger Institute and WormBase, as part of the 50 Helminth Genomes project. An in-house pipeline was developed that used MAKER to generate high-quality annotations by integrating evidence from multiple sources: ab initio gene predictions from AUGUSTUS, GeneMark-ES, and SNAP; projected annotation from C. elegans (using GenBlastG) and the taxonomically nearest reference helminth genome (using RATT); and ESTs, mRNAs and proteins from related organisms aligned to the genome using BLAST, with refinement of alignments using Exonerate.

Key Publications

Assembly Statistics

AssemblyN_brasiliensis_RM07_v1_5_4_0011_upd, GCA_900618405.1
Database VersionWBPS18
Genome Size294,400,206
Data SourceWellcome Sanger Institute
Annotation Version2014-06-50HGPpatch

Gene counts

Coding genes22,796
Gene transcripts22,796

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