About Onchocerca ochengi
The nematode Onchocerca ochengi is a filarial parasite of cattle, and is native to West Africa, including Cameroon. O. ochengi is very closely related to the human-parasitic Onchocerca volvulus, the tractability of the bovine host makes the O. ochengi-cattle model a useful one in vaccine and drug development work for Onchocerca.
There is 1 alternative genome project for Onchocerca ochengi available in WormBase ParaSite: PRJEB1465
Genome Assembly & Annotation
The draft genome assembly was produced by the Parasite Genomic group at the Wellcome Trust Sanger Institute, in collaboration with Sara Lustigman (New Yourk Blood Center) as part of the 50 Helminth Genomes project. The assembly uses Illumina paired-end sequencing followed by an in-house genome assembly pipeline comprising various steps, including contig assembly, scaffolding, gap-filling and error-correction.
The gene predictions were made by the Parasite Genomics group at the Wellcome Trust Sanger Institute and WormBase, as part of the 50 Helminth Genomes project. An in-house pipeline was developed that used MAKER to generate high-quality annotations by integrating evidence from multiple sources: ab initio gene predictions from AUGUSTUS, GeneMark-ES, and SNAP; projected annotation from C. elegans (using GenBlastG) and the taxonomically nearest reference helminth genome (using RATT); and ESTs, mRNAs and proteins from related organisms aligned to the genome using BLAST, with refinement of alignments using Exonerate.
- International Helminth Genomes Consortium. Comparative genomics of the major parasitic worms. Nat Genet, 2019;51(1):163-174
|Wellcome Sanger Institute
This widget has been derived from the assembly-stats code developed by the Lepbase project at the University of Edinburgh