WormBase ParaSite HomeVersion: WBPS19 (WS291)-  Archive: WBPS18

Wuchereria bancrofti

BioProject PRJNA275548 | Data Source Case Western Reserve University | Taxonomy ID 6293

About Wuchereria bancrofti

The nematode Wuchereria bancrofti is a human parasite that is the major cause of lymphatic filariasis. It is the most prevalent human infective filarial worm, affecting over 120 million people, primarily in Central Africa and the Nile delta, South and Central America, and the tropical regions of Asia. If the infection is left untreated, it can develop into elephantiasis.

There is 1 alternative genome project for Wuchereria bancrofti available in WormBase ParaSite: PRJEB536

Genome Assembly & Annotation

Assembly

As described in Small et al 2019, PacBio sequencing using chemistry RS II was performed on DNA isolated from the Wuchereria bancrofti samples from Small et al 2016. Ten PacBio SMRT cells were run for an estimated coverage of 20-40X. Whole genomes were aligned using progressiveCactus with a guide tree reconstructed from whole mitochondrial genomes (Small et al. 2014‚Ā†). Scaffolds were assigned to chromosomes using Ragout (Kolmogorov et al. 2014). Scaffolds were named according to B. malayi reference genome.

This is an update to the older GCA_001555675.1 W. bancrofti genome by Small et al 2016.

Annotation

Homology-based gene predictions were generated in GeMoMa using B. malayi gene models (PRJNA10729). These predictions were supplemented with ab initio gene predictions from BRAKER2, trained using B. malayi, which were refined based on transcript and protein homology evidence from related filarial worm species in MAKER. The annotation has been generated and provided by the Mitreva Lab at Washington University School of Medicine in St. Louis .

Key Publications

Assembly Statistics

AssemblyASM528172v1, GCA_005281725.1
Strain17-3
Database VersionWBPS19
Genome Size88,416,250
Data SourceCase Western Reserve University
Annotation Version2023-09-WormBase

Gene counts

Coding genes11,166
Gene transcripts11,166

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