About Haemonchus contortus
The nematode Haemonchus contortus, or red stomach worm, wire worm or Barber's pole worm, is an animal endoparasite infecting wild and domesticated ruminants (including sheep and goats) worldwide. It is a very common parasite and one the most pathogenic nematodes of ruminants. Adult worms are attached to abomasal mucosa and feed on the blood. H. contortus is a close relative of the human hookworm species which makes it an important model of parasitic nematode biology that is commonly used for experimental studies.
There is 1 alternative genome project for Haemonchus contortus available in WormBase ParaSite: PRJNA205202
Genome Assembly & Annotation
The assembly presented here has been sequenced at the Parasite Genomics group at the Wellcome Trust Sanger Institute. The previous reference genome (Laing et al. (2013)) was improved through additional sequencing with long PacBio reads and optical mapping, giving a chromosome-level assembly. Manuscript in preparation.
The gene models were made by the Parasite Genomics group at the Wellcome Sanger Institute using an automated prediction tool BRAKER1 to generate preliminary gene models, which were subsequently improved using IsoSeq, incorporating orthologs using PASA and EVidenceModeler, and ongoing manual curation. The annotation presented here is a snapshot from Spring 2020.
- Laing R, Kikuchi T, Martinelli A, Tsai IJ, Beech RN, Redman E, Holroyd N, Bartley DJ, Beasley H, Britton C, Curran D, Devaney E, Gilabert A, Hunt M, Jackson F, Johnston SL, Kryukov I, Li K, Morrison AA, Reid AJ, Sargison N, Saunders GI, Wasmuth JD, Wolstenholme A, Berriman M, Gilleard JS, Cotton JA. The genome and transcriptome of Haemonchus contortus, a key model parasite for drug and vaccine discovery. Genome Biol, 2013;14(8):R88
- Doyle SR, Tracey A, Laing R, Holroyd N, Bartley D, Bazant W, Beasley H, Beech R, Britton C, Brooks K, Chaudhry U, Maitland K, Martinelli A, Noonan JD, Paulini M, Quail MA, Redman E, Rodgers FH, Sallé G, Shabbir MZ, Sankaranarayanan G, Wit J, Howe KL, Sargison N, Devaney E, Berriman M, Gilleard JS, Cotton JA. Genomic and transcriptomic variation defines the chromosome-scale assembly of Haemonchus contortus, a model gastrointestinal worm. Commun Biol, 2020;3(1):656
|Data Source||Wellcome Sanger Institute|
This widget has been derived from the assembly-stats code developed by the Lepbase project at the University of Edinburgh