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Onchocerca volvulus

BioProject PRJEB513 | Data Source WormBase | Taxonomy ID 6282

About Onchocerca volvulus

The nematode Onchocerca volvulus is a gonochoristic filarial parasite of humans causing Onchocerciasis. Onchocerciasis, or River Blindness, is a neglected tropical disease (NTD) which affects over 37 million people, mainly in Africa. It is a severely debilitating disease, which is transmitted to humans by the bite of Simulium blackflies that live and breed near fast-flowing streams and rivers.

Genome Assembly & Annotation


The reference genome for Onchocerca volvulus has been produced by the Parasite Genomics group at the Wellcome Trust Sanger Institute, in collaboration with Sara Lustigman (New York Blood Center). A combination of deep sequencing and optical mapping was used on material from a single adult worm from the Republic of Cameroon.


The gene models are actively curated by WormBase.

Key Publications

  • Cotton JA, Bennuru S, Grote A, Harsha B, Tracey A, Beech R, Doyle SR, Dunn M, Hotopp JC, Holroyd N, Kikuchi T, Lambert O, Mhashilkar A, Mutowo P, Nursimulu N, Ribeiro JM, Rogers MB, Stanley E, Swapna LS, Tsai IJ, Unnasch TR, Voronin D, Parkinson J, Nutman TB, Ghedin E, Berriman M, Lustigman S. The genome of Onchocerca volvulus, agent of river blindness. Nat Microbiol, 2016;2():16216

Assembly Statistics

AssemblyASM49940v2, GCA_000499405.2
StrainO. volvulus Cameroon isolate
Database VersionWBPS19
Genome Size96,427,137
Data SourceWormBase
Annotation Version282

Gene counts

Coding genes12,109
Non coding genes457
Small non coding genes457
Gene transcripts13,945

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This widget has been derived from the assembly-stats code developed by the Lepbase project at the University of Edinburgh