About Toxocara canis
The nematode Toxocara canis, or dog roundworm, is a worldwide-distributed intestinal parasite of dogs and other canids, and is thought to be the most common parasite infection of humans in the United States of America. It has a wide host range. Humans are infected by accidental ingestion of infective eggs from dog faeces, causing toxocariasis, an infection of organs such as the liver, lungs, eyes or brain. T. canis has many characteristics that make it a useful model system.
There is 1 alternative genome project for Toxocara canis available in WormBase ParaSite: PRJNA248777
Genome Assembly & Annotation
The draft genome assembly was produced by the Parasite Genomic group at the Wellcome Trust Sanger Institute, in collaboration with Philip Cooper (Liverpool School of Tropical Medicine) as part of the 50 Helminth Genomes project. The assembly uses Illumina paired-end sequencing followed by an in-house genome assembly pipeline comprising various steps, including contig assembly, scaffolding, gap-filling and error-correction.
The gene predictions were made by the Parasite Genomics group at the Wellcome Trust Sanger Institute and WormBase, as part of the 50 Helminth Genomes project. An in-house pipeline was developed that used MAKER to generate high-quality annotations by integrating evidence from multiple sources: ab initio gene predictions from AUGUSTUS, GeneMark-ES, and SNAP; projected annotation from C. elegans (using GenBlastG) and the taxonomically nearest reference helminth genome (using RATT); and ESTs, mRNAs and proteins from related organisms aligned to the genome using BLAST, with refinement of alignments using Exonerate.
- International Helminth Genomes Consortium. Comparative genomics of the major parasitic worms. Nat Genet, 2019;51(1):163-174
|Data Source||Wellcome Sanger Institute|
This widget has been derived from the assembly-stats code developed by the Lepbase project at the University of Edinburgh